Cisternal Rab Proteins Regulate Golgi Apparatus Redistribution in Response to Hypotonic Stress
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چکیده
منابع مشابه
Cisternal rab proteins regulate Golgi apparatus redistribution in response to hypotonic stress.
We show that a physiological role of the extensively studied cisternal Golgi rab protein, rab6, is modulation of Golgi apparatus response to stress. Taking exposure of cells to hypotonic media as the best-known example of mammalian Golgi stress response, we found that hypotonic-induced tubule extension from the Golgi apparatus was sensitive to GDP-rab6a expression. Similarly, we found that Golg...
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Current models entail that transport through the Golgi-the main sorting compartment of the cell-occurs via cisternal progression/maturation and that Ypt/Rab GTPases regulate this process. However, there is very limited evidence that cisternal progression is regulated, and no evidence for involvement of Ypt/Rab GTPases in such a regulation. Moreover, controversy about the placement of two of the...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2005
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e04-10-0861